Clinical implications of molecular markers in acute myeloid leukemia

New Molecular Markers in Acute Myeloid Leukemia

Molecular Genetic Markers in Acute Myeloid Leukemia

Genetics play an increasingly important role in the risk stratification and management of acute myeloid leukemia (AML) patients. Traditionally, AML classification and risk stratification relied on cytogenetic studies; however, molecular detection of gene mutations is playing an increasingly important role in classification, risk stratification, and management of AML. Molecular testing does not ...

The role of microRNA in acute/chronic, myeloid/lymphocytic leukemia

MicroRNAs are small, non-coding sequences that regulate gene expression by inducing degradation or translational inhibition of target mRNAs. These molecules control many intracellular physiological and pathological processes.Abnormal expression of these moleculs has been described in different cancers including hematopoietic cancers. According to the type of cancer and the stage, miRNA’s expres...

Review Series ADVANCES IN ACUTE MYELOID LEUKEMIA Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance

Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance David Grimwade, Adam Ivey, and Brian J. P. Huntly Department of Medical & Molecular Genetics, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom; Department of Haematology, Cambridge Institute for Medical Research and Addenbrookes Hospital, University of Cambridge, and We...

PROGNOSTIC VALUE OF MYELOID ANTIGEN EXPRESSION IN ACUTE LYMPHOBLASTIC LEUKEMIA

Expression of cell surface molecules associated with lymphoid and myeloid lineage differentiation on the blasts of 53 patients with acute lymphoblastic leukemia (ALL) was investigated. 1.9% of cases were only HLA"7DR+ 7.6% were HLA-DR+, CDI9+ 22.6% were HLA-DR+, CDI9+, CDI0+ 30.2% were HLADR+, CDI9+, CDlO±, CD20+ and 37.7% were HLA-DR±, CD7+, CD5±. Aberrant expression of one or more myeloi...